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KMID : 1200820210210020323
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Oriental Pharmacy and Experimental Medicine
2021 Volume.21 No. 2 p.323 ~ p.329
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A pilot study of pain-relieving effect of Goreisan in glossodynia with dry mouth symptoms: an open-label single-group study
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Okayasu Ichiro
Mizuki Tachi
Sanuki Takuro
Kurata Shinji
Ayuse Takao
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Abstract
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Goreisan might be a medicine to cure the pain caused by thirst and dry mouth symptom of glossodynia. All registered patients were treated with Goreisan by taking 7.5 g / day (min 3) for 2 weeks. Self-filled Visual Analogue Scale (VAS) and tongue perception test by nomo-filament. Furthermore, daily self-filled VAS evaluation was required patients’ home for two weeks during Goreisan administration. There was 57% of patients (8/14) showed “improved” after administration of 2 weeks Goreisan administration based on the criteria of 20% reduction of VAS compared to baseline. Self-filled VAS score was significant low (p?=?0.006) at 2 weeks evaluation at second visit and remained lower level through 4 week observation periods compared to baseline value. QST significantly increased after 2 weeks administration of Goreisan (p?=?0.008) and remained higher level through 4 week observation periods compared to baseline value. There was significant reduction of daily self-filled VAS patients’ home at day 3 and day 13?~?day 14. (p?
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KEYWORD
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Goreisan, Glossalgia, Pain perception, Visual analogue scale
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