|
KMID : 1200820210210030485
|
|
Oriental Pharmacy and Experimental Medicine
2021 Volume.21 No. 3 p.485 ~ p.498
|
|
|
Antimicrobial and antidiarrhoeal activities of aqueous and methanolic extracts of Mangifera indica Linn stem bark (Anarcadiaceae) in Wistar rats
|
|
Tchoumi L. M. Tchoumba
Nchouwet M. L.
Kamani S. L. Poualeu
Nana W. Yousseu
Djimeli R. C. Douho
Kamanyi A.
Ngnokam S. L. Wansi
|
|
|
Abstract
|
|
|
|
Diarrhea is one of the leading causes of infant mortality in developing country. It has been reported that Mangifera indica is used as an antidiarrhoeal agent in traditional medicine. Thus, the aim of this study was to evaluate the antimicrobial and antidiarrhoeal activities of aqueous and methanolic extracts of Mangifera indica Linn stem bark. The extracts were tested in vitro on the growth of bacteria and fungi; and in vivo at doses of 300, 400 and 500 mg/kg on the effects of Escherichia coli, castor oil, misoprostol and charcoal meal in rats. In vitro, the methanolic extract was the most active with a minimum inhibitory concentration (MIC) of 256 μg/mL for all Gram negative and Gram postive bacteria tested; the value of MIC for all fungi tested was 32 μg/mL. In vivo, the aqueous extract at doses of 300 and 500 mg/kg and methanolic extract at dose of 500 mg/kg resulted in a significant decrease (p?
|
|
|
KEYWORD
|
|
|
Mangifera indica, Aqueous extract, Methanolic extract, Antimicrobial, Antidiarrheal
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|