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KMID : 1200820210210030499
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Oriental Pharmacy and Experimental Medicine
2021 Volume.21 No. 3 p.499 ~ p.506
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Comparative neuropharmacological and Cytotoxic profiles of Alstonia scholaris (L.) and Mimusops elengi (L.) leaves
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Sarkar Kishore Kumar
Rahman Md. Muzibar
Shahriar Abdullah Al Ehsan
Mitra Trina
Golder Mimi
Zilani Md. Nazmul Hasan
Biswas Biswajit
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Abstract
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Mimusops elengi Linn. is traditionally used as antianxiety, cytotoxic, antimicrobial, antioxidants etc. Also, conventionally, Alstonia scholaris Linn. is used in treating cancer, psychosis, nociception etc. The present study was designed to appraise neuropharmacological and cytotoxic potential of M. elengi and A. scholaris leaves. Hole cross and hole board tests were conducted for assessing sedative effect, thiopental sodium induced sleeping time test for hypnotic property, elevated plus maze (EPM) test for anxiolytic potential, tail suspension test for antidepressant effect and finally brine shrimp lethality bioassay for evaluating cytotoxic potential of both extracts. In both hole cress and hole board tests, M. elengi leaves (MEL) displayed greater locomotion reduction compared to A. scholaris leaves (ASL). Besides, in thiopental sodium induced sleeping time and EPM test, both extracts confirmed significant (p?
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KEYWORD
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Mimusops elengi, Alstonia scholaris, Sedative, Hypnotic, Anxiolytic, Cytotoxicity
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