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KMID : 1200820210210040675
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Oriental Pharmacy and Experimental Medicine
2021 Volume.21 No. 4 p.675 ~ p.683
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Evaluation of classical ayurvedic medicine “Sukumaram Kasayam” in a rat model of letrozole induced polycystic ovaries
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Dash Sujit
Kanungo Sunil Kumar
Mishra Bishwanath
Sahoo Amaresh Chandra
Senapati Aswini Kumar
Pattnaik Sangyarani
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Abstract
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PCOS is considered as common endocrine diseases among the females in their regenerative age. The purpose of the study was to analyze phytochemicals by GC?MS followed by the pharmacological evaluation of Sukumaram Kasayam on PCOS induced rats. GC?MS analysis of Sukumaram Kasayam was accomplish to identify phytoconstituents. Twenty-four female rats were used (n?=?6/group) in the study consisting of healthy control (Group-I). The experimental groups were divided into 3 subgroups, including rats with PCOS which received no treatment (Group-II), PCOS group (Group-III and Group-IV) was administered daily dose of Clomifene citrate 200 mg/kg and Sukumaram Kasayam 0.5 ml/kg for 3 weeks, respectively. In all experimental groups, oral dose of 1 mg/kg letrozole for 21 days to induce PCOS. After treatment period, rats were anesthetized, blood sex hormone and lipid profile was carried. The GC?MS analysis identified Butane, 1, 1-diethoxy-3-, (+)-2-Bornanone abundant compound in formulation. The PCOS induced rats were treated with Clomiphene citrate, Sukumaram Kasayam, the testosterone decreased significantly (P?
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KEYWORD
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Sukumaram Kasayam, GC?MS, Letrozole, Polycystic ovarian syndrome, Wistar albino female rat
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