|
KMID : 1200820210210040815
|
|
Oriental Pharmacy and Experimental Medicine
2021 Volume.21 No. 4 p.815 ~ p.824
|
|
|
Antiproliferative and ameliorative effects of Tetracera potatoria and its constituent
|
|
Ogunlakin Akingbolabo Daniel
Sonibare Mubo Adeola
Jabeen Almas
Shaheen Farzana
Shah Syeda Farah
|
|
|
Abstract
|
|
|
|
The effect of Tetracera potatoria leaves and its isolated constituent on polycystic ovarian syndrome (PCOS) and associated gynaecological cancers was investigated. Crude extract showed the lowest level of luteinizing hormone and the highest level of estradiol and follicle stimulating hormone, comparable to the normal control group. The hexane (IC50?=?34.8?±?0.3 μg/mL), and dichloromethane (IC50?=?41.3?±?0.8 μg/mL) fractions inhibited the proliferation of Chinese Hamster ovarian (CHO) cells. The dichloromethane fraction was subjected to purification using column chromatography, which led to the isolation of apigenin. The structure of the isolated compound was confirmed by the reported spectroscopic data. Apigenin inhibited the proliferation of both CHO and HeLa cells with an IC50 values of 22.2?±?0.5 and 6.2?±?0.6 μg/mL, respectively. The apigenin was isolated and reported for the first time in T. potatoria. The leaves extract of T. potatoria showed curative effect on irregular estrus cycle and hormonal imbalance. The isolated constituent showed anticancer potential, hence it could reduce the risk of gynaecological cancers among PCOS patients.
|
|
|
KEYWORD
|
|
|
Tetracera potatoria, Antiproliferative, Flavonoids, Polycystic ovary syndrome, Luteinizing hormone, Follicle stimulating hormone
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|