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KMID : 1200820220220010075
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Oriental Pharmacy and Experimental Medicine
2022 Volume.22 No. 1 p.75 ~ p.90
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Chemical composition, in vitro antioxidant, and enzymes inhibitory potential of three medicinally important plants from Nepal (Lepisorus mehrae, Pleurospermum benthamii, and Roscoea auriculata)
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Pandey Bishnu Prasad
Pradhan Suman Prakash
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Abstract
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The aim of this study was to examine antioxidant properties, major enzyme inhibition activities, and targeted metabolites profiling of Lepisorus mehrae, Pleurospermum benthamii, and Roscoea auriculata in different solvent extracts. This is the first report on metabolites profiling and biochemical activities of these plant species. Our results revealed that L. mehrae, P. benthamii, and R. auriculata are rich source of bioactive secondary metabolites and have good antioxidant potential. The methanol extract of L. mehrae, P. benthamii, and R. auriculata showed substantial inhibitory potential towards elastase, whereas water extract of L. mehrae and R. auriculata were more strong inhibitors of tyrosinase. Among the three plants, P. benthamii showed noteworthy inhibition on α-amylase, α-glucosidase, lipase, tyrosinase, elastase, and cholinesterases enzymes. High resolution mass spectrometry analysis revealed the presence of metabolites such as Protocatechuic acid, Gallic acid, 7,8,3′,4′-tetrahydroxyflavanone, Rhamnocitrin, Quercetin, Hyperoside, Quercetin-7-glucoside, Rutin, Rhamnetin, Aromadendrin, Camphor, and Hexanoic acid in L. mehrae. Moreover, Catechin and Fisetin were present in P. benthamii and Kaempferide, 7,8,3′,4′-Tetrahydroxyflavone, 5,7-Dihydroxy-2,3-dihydroflavonol 3-acetate, and Aromadendrin were present in R. auriculata. The results presented here provide enough scientific evidence that these plant species have diverse biochemical potential and can be examined further for their potential use in modern pharmaceuticals, cosmetics, and nutraceuticals.
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KEYWORD
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Lepisorus mehrae, Pleurospermum benthamii, Roscoea auriculata, Enzymes inhibition, Antioxidant, Metabolites
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