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KMID : 1200820220220010099
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Oriental Pharmacy and Experimental Medicine
2022 Volume.22 No. 1 p.99 ~ p.106
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In silico effect of Korean medicinal phytocompounds on gene targets of osteoarthritis
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Shah Fahad Hassan
Kim Song-Ja
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Abstract
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Traditional Korean medicinal plants are known for their medieval and traditional therapeutic purposes. These plants were used in different concentrations to treat challenging diseases, maximize therapeutic influence, and promote patient wellbeing. The phytochemicals of these plants possess antimicrobial, anti-inflammation, and anti-cancer properties. In comparison, traditional Chinese plant extracts and their compounds are more elaborately explored in the treatment of osteoarthritis (OA). Therefore, in this study we aimed to analyze the effects of major phytocompounds of five antioxidant Korean medicinal plants on potential gene targets of OA. This was done using an in silico gene expression database in order to evaluate the rate of expression. We selected major compounds of these plants and utilized PubChem to download the canonical SMILES, thus determining their effect on genes using the DIGEP-Pred database. The results of our analysis showed that the Korean medicinal compounds reduced the expression of SUV39H2, MIR20B, SOX4, KLF10, DNMT1, SUMO1, LGALS8, IL15, SPRY1, IL1R1, CXCL2 and APOA1, all of which are implicated in the pathogenesis of OA. They also increased the expression of COL2A1, OGG1, GCLC, HOXA11, KEAP1, FOXO1, CITED2 and BMPR1B, which are involved in the repair and maintenance of articular cartilage. Our study also demonstrated the promising activity of the Korean medicinal compounds against OA and the possession of gene targeting effects. The results of this study might be used to validate these effects in-vitro experiments.
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KEYWORD
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Osteoarthritis, Korean medicinal plants, Phytocompounds, Insilico gene expression, Antioxidant compounds
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