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KMID : 1200820220220010177
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Oriental Pharmacy and Experimental Medicine
2022 Volume.22 No. 1 p.177 ~ p.191
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Anticonvulsant effect and acute toxicity study of the aqueous lyophilized extract of four medicinal plants of Cameroon: Malvaviscus arboreus, Alchemilla kiwuensis and mixture of Drymaria cordata and Markhamia lutea
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Ngoupaye Gwladys Temkou
Adassi Maxwell Blesdel
Foutsop Aurelien Fossueh
Noungoua Chretien Mbeugangkeng
Yaya Joel
Kom Tatiana Diebo
Bum Elisabeth Ngo
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Abstract
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Epilepsy is a chronic disease of the central nervous system that affects nearly 1% of the world's population and remains a major public health problem in sub-Saharan. This study aimed at investigating anticonvulsant effects and acute toxicity of four Cameroonian medicinal plants: Malvaviscus arboreus (M. arboreus), Alchemilla kiwuensis (A. kiwuensis), and mixture of Drymaria cordata (D. cordata) and Markhamia lutea (M. lutea). Acute epileptic seizures were induced on Swiss mice of both sexes with pentylenetetrazole (70 mg/kg), picrotoxin (7.5 mg/kg) and strychnine (2.5 mg/kg). Acute toxicity and qualitative phytochemical tests of plants were further perfomed. M. arboreus protected 71.43% of subjects against pentylenetetrazole-induced seizures at 688 mg/kg (p?
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KEYWORD
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Epilepsy, Acute toxicity, Malvaviscus arboreus, Achemilla kiwuensis, Drymaria cordata, Markhamia lutea
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