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KMID : 1200820220220020347
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Oriental Pharmacy and Experimental Medicine
2022 Volume.22 No. 2 p.347 ~ p.358
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Tetrorchidium didymostemon leaf extract reduces Plasmodium berghei induced oxidative stress and hepatic injury in Swiss albino mice
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Ebohon Osamudiamen
Irabor Francis
Ayevbuomwan Merit Esewi
Omoregie Ehimwenma Sheena
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Abstract
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Oxidative stress, already implicated in malaria infection has been identified as one of the major contributors to the pathophysiology of malaria. This study was aimed at evaluating the effects of methanol extracts of Tetrorchidium didymostemon leaf and stem bark on Plasmodium berghei induced oxidative stress in the liver, spleen and brain of mice. P. berghei-infected mice were sacrificed on day 5 of the experiment after four days of consecutive administration of T. didymostemon extracts (250 and 500 mg/kg body weight). Thereafter, biochemical analysis and histopathological examination were carried out. The leaf extract had a significantly higher (P?
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KEYWORD
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Tetrorchidium didymostemon, Malaria, Histopathology, Splenomegaly, Antioxidant enzymes, Hepatic function
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