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KMID : 1200820220220030557
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Oriental Pharmacy and Experimental Medicine
2022 Volume.22 No. 3 p.557 ~ p.567
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Toxicity profile of Phaleria macrocarpa (Scheff.) Boerl. fruits extract in adult male Sprague-Dawley rats
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Azad Abul Kalam
Sulaiman Wan Mohd Azizi Wan
Kundu Sukalyan Kumar
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Abstract
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The fruits of Phaleria macrocarpa (PM) have long been used as a traditional Malay medicinal herb for hundreds of years. To determine the toxicity of the mesocarp and pericarp of ethanol extract of PM (EEPM). In this study, 6?8 weeks of adult healthy male Sprague-Dawley (SD) rats between 180 and 220 g, were used. The Group I was received 10?% normal saline and Group II, III, IV and V were treated with EEPM orally to each rat (n?=?6) on daily basis at 500, 1000, 2000 and 5000 mg/kg 28 consecutive days. Animals body weight showed normal growth from 189.76?±?2.33 and 189.86?±?1.01 g to 227?±?3.06 and 225?±?2.07 g. Biochemical aspects of treated animals’ indicated serum values of (creatinine 0.46?±?0.033, phosphorous 5?±?0.46, HDL 31.31?±?1.48, LDL 30.66?±?0.37, Cholesterol 68.23?±?1.28 and AST 63.08?±?2.65, ALT 22.05?±?0.68 and ALP 79.16?±?0.82) which is similar with the control group. Histological observation showed no necrosis, abnormalities and inflammation in both control and EEPM treated groups. Findings suggests; the fruits are non-toxic when applied to SD rats. In this way, it may also serve as a good alternative in the present armamentarium of traditional medicine without showing its any side effects.
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KEYWORD
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P. macrocarpa, Toxicity, EEPM, Histology, Kidney, Pancreas
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