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KMID : 1200820220220030589
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Oriental Pharmacy and Experimental Medicine
2022 Volume.22 No. 3 p.589 ~ p.597
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Assessment of wound healing activity of ethanolic extracts of Pistacia lentiscus L. leaves and Quercus ilex L. bark in full thickness skin excision in rats
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Hemida Houari
Doukani Koula
Zitouni Abdelkader
Miloud Brahim
Beggar Houcine
Bouhenni Hasna
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Abstract
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The objective of our study was to evaluate the wound healing effect of ethanolic extracts of pistachio (Pistacia lentiscus L.) leaves and holm oak (Quercus ilex L.) bark on full-thickness excisions (4 cm2) in Wistar rats. Forty-two rats were divided into seven equal groups that received different treatments; two groups were treated with Quercus ilex bark extract (10% and 30%), two other groups with Pistacia lentiscus leaves extract (10% and 30%), one group received Cicatryl-bio® and considered as a positive control, a group treated with pure Petroleum jelly, and the last was left as an untreated negative control. The evaluation of the excision zones was estimated by a planimetric study using an image processing software (ImageJ®) and histological examination of healed skin tissue. The results revealed that Pistacia lentiscus leaves and Quercus ilex bark promote wound healing effect because they accelerated wound contraction and reduced epithelialization period. Ointments prepared from Quercus ilex bark and Pistacia lentiscus leaves ethanolic extracts exhibited effective wound healing action in Wistar rat’s skin excisions. Both preparations showed an accelerated healing process compared to the other formulations. To the best of the author's knowledge, this is the first study of wound healing effect of pistachio (Pistacia lentiscus) leaves and holm oak (Quercus ilex) bark.
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KEYWORD
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Pistacia lentiscus, Quercus ilex, Wound healing, Rats, Skin excision
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