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KMID : 1200820220220030631
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Oriental Pharmacy and Experimental Medicine
2022 Volume.22 No. 3 p.631 ~ p.640
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Effects of aqueous extract of Anogeissus leiocarpus (DC) guill. Et Perr. (Combretaceae) leaves on acetic acid?induced ulcerative colitis in rats
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Tagne Michel Archange Fokam
Noubissi Paul Aime
Gaffo Estelle Flora
Fankem Gaetan Olivier
Mukam Joseph Ngakou
Kamgang Rene
Oyono Jean-Louis Essame
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Abstract
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Colitis are one of the worldwide increasing inflammatory bowel diseases. Colitis was induced by intrarectal administration of 1 mL of acetic acid (4%) in rats. The normal and the colitis controls treated with distilled water, the positive control treated with dexamethasone (5 mg/kg), and two test groups treated with extract at 100 and 200 mg/kg bw for seven days. During treatment, the number and quality of stools as well as changes in body weight and body temperature were assessed. At the end, animals were sacrificed; blood and colon were taken for the assay of oxidative stress, hematological and histological parameters. The diarrheal stools and the body temperature significantly (P?
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KEYWORD
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Anogeissus leiocarpus, Ulcerative colitis, Acetic acid, Oxidative stress, Hematology
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