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KMID : 1201620100030020043
Journal of Women s Medicine
2010 Volume.3 No. 2 p.43 ~ p.50
Risk factors and pattern of treatment failures in patients with borderline ovarian tumors
Kim Ki-Dong

Cho Soo-Youn
Chung Hyun-Hoon
Abstract
Objective: The objective of this study was to investigate the risk factors and pattern of treatment failures of borderline ovarian tumors (BOTs) by retrospectively examining the clinicopathologic variables of patients with BOTs.


Methods: The clinicopathologic variables on 209 patients with BOTs who were diagnosed and treated in our institute between January 1988 and July 2007 were extracted via medical records review. The clinicopathologic variables included age, menopausal status, type of surgery, histologic type, stage, gross residual disease, peritoneal implants, microinvasion, and adjuvant chemotherapy. Treatment failure was defined as recurrent or persistent diseases after primary treatment. The associations of clinicopathologic variables with treatment failure were investigated using univariate and multivariate analysis.

Results: During the follow?up period (median, 29 month; range, 1 to 232 months), one tumor?related death and nine treatment failures were observed. Based on univariate analysis, treatment failure was associated with stage 1C or greater, gross residual disease, peritoneal implants and adjuvant chemotherapy. However, based on multivariate analysis, only stage 1C or greater (OR, 15.7; 95% CI, 1.4 to 180.6) was associated with treatment failure. Eight of nine treatment failures were intraperitoneal. Patients who received a conservative surgery tended to suffer a treatment failure in pelvic cavity, but patients who received a radical surgery tended to experience an extra?pelvic recurrence.

Conclusion: In patients with BOTs, stage 1C or greater was associated with treatment failure. Most recurrent or persistent diseases were confined to peritoneal cavity.
KEYWORD
Borderline ovarian tumor, Low malignant potential ovarian tumor, Ovarian neoplasm, Recurrence, Stage
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