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KMID : 1201620100030020051
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Journal of Women s Medicine
2010 Volume.3 No. 2 p.51 ~ p.56
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Two-dimensional Largest ovarian area to predict ovarian response in in vitro fertilization cycle
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Kim Sang-Don
Jee Byung-Chul
Suh Chang-Suk
Kim Seok-Hyun
Choi Young-Min
Kim Jung-Gu
Moon Shin-Yong
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Abstract
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Objective: To evaluate the usefulness of two dimensional largest ovarian area (LOA) as a predictive parameter of oocyte yield and pregnancy in in vitro fertilization (IVF) cycle.
Methods: Ninety?two stimulated IVF cycles from sixty?eight infertile women were included. On the day 3 of cycles, antral follicle count (AFC) and LOA were measured by ultrasonography before starting gonadotropins. LOA was calculated by ellipsoid formula (D1×D2×0.8) using two perpendicular diameters in the largest cross?sectional view of each ovary and then summed.
Results: Both LOA and AFC had a positive correlation with the number of retrieved oocytes. The best cut?off value of LOA was 6.14 cm2 for predicting poor ovarian response (area under curve [AUC], 0.783; 95% confidence interval [CI], 0.684 to 0.862), 7.70 cm2 for predicting cycle cancellation (AUC, 0.794; 95% CI, 0.697 to 0.871) and 8.36 cm2 for predicting pregnancy (AUC, 0.641; 95% CI, 0.534 to 0.739). For AFC, the best cut?off value was 9 for poor ovarian response (AUC, 0.877; 95% CI, 0.792 to 0.936), 6 for predicting cycle cancellation (AUC, 0.942; 95% CI, 0.872 to 0.980) and 9 for pregnancy (AUC, 0.683; 95% CI, 0.578 to 0.776). The predictability for pregnancy was similar between LOA and AFC.
Conclusion: LOA is easy to measure and a good marker for predicting ovarian response and IVF pregnancy.
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KEYWORD
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Ovarian response, Ultrasonography, Antral follicle count, Ovarian size, In vitro fertilization
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