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KMID : 1201620100030040155
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Journal of Women s Medicine
2010 Volume.3 No. 4 p.155 ~ p.158
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Efficacy of luteal supplementation of vaginal sildenafil and oral estrogen on pregnancy rate following IVF-ET in women with a history of thin endometria: A pilot study
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Kim Kwang-Rae
Lee Hee-Sun
Ryu Hyoung-Eun
Park Chun-Young
Min Se-Hee
Park Chan
Jee Byung-Chul
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Abstract
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Objective: The several strategies for unexplained thin endometrium are under debate. We evaluated the effect of concomitant administration of vaginal sildenafil and oral estrogen in women with a thin endometrium undergoing in vitro fertilization (IVF).
Methods: Forty-eight women showing thin endometrium less than 8 mm at the time of embryo transfer were randomly assigned to the study (n=21) and control group (n=27) in their subsequent IVF cycles. Routine luteal support was made by vaginal micronized progesterone 600 mg/day. In the study group, oral estradiol valerate 4 mg/day + vaginal sildenafil 25 mg/day was administered from the day of embryo transfer.
Results: The clinical pregnancy rate was two-fold higher in the study group, although it was not statistically significant (47.6% vs. 25.9%, P=0.209).
Conclusion: Our study supports that luteal administration of vaginal sildenafil and oral estrogen has modest beneficial impact on the uterine receptivity.
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KEYWORD
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Thin endometrium, Vaginal sildenafil, Estrogen, in vitro fertilization
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