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KMID : 1201620110040010006
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Journal of Women s Medicine
2011 Volume.4 No. 1 p.6 ~ p.10
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Endometrial expression of HCG/LH receptor in infertile women with repeated implantation failure
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Jee Byung-Chul
Suh Chang-Suk
Kim Seok-Hyun
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Abstract
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Objective: To investigate endometrial expression of human chorionic gonadotropin (HCG)/luteinizing hormone (LH) receptor in infertile women who experienced repeated implantation failure.
Methods: Sixty-one women participating in vitro fertilization due to unexplained infertility (n=37) or male factor (n=24) were included. Endometrial biopsies were taken during luteal phase in a spontaneous unmedicated cycle. The streptavidin-biotin-peroxidase complex technique was used for immunohistochemistry. The signal intensity was assigned semiquantitatively and then compared between the repeated implantation failure group (three or more failures, n=33) and controls (two or less failures, n=28).
Results: Luteal expressions of HCG/LH receptor at all three compartments were not different statistically between the two groups. However, late luteal expressions of HCG/LH receptor tended to be consistently low in repeated implantation failure group. In repeated implantation failure group, HCG/LH receptor expression continuously decreased throughout the entire luteal phase.
Conclusion: Low expression of HCG/LH receptor in late luteal endometrium might contribute to repeated implantation failure.
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KEYWORD
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Endometrium, HCG/LH receptor, In vitro fertilization, Implantation
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