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KMID : 1204320060220040355
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Laboratory Animal Research
2006 Volume.22 No. 4 p.355 ~ p.360
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Single Oral Dose Toxicity Test of Water Extracts of Mori radicis Cortex in ICR Mice
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Ree Jung-Woo
Ku Sae-Kwang
Seong Seung-Kyoo
Lee Sang-Ho
Kim Yong-Sung
Leem Moon-Jeong
Oh Seong-Jun
Ryu Jei-Man
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Abstract
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The object of this study was to obtain acute information of lyophilized water extract of Mori radicis (MR) cortex in male and female mice. In order to observe the 50% lethal dose (LD50), approximate lethal dosage (LD) and target organs, test articles were once orally administered to female and male ICR mice at dose levels of 2,000 and 0 (control) mg/kg (body weight) according to the recommendation of KFDA Guidelines. The mortality and changes in body weight, clinical signs and gross observation were monitored during 14 days after dosing, in addition to organ weight and histopathology of 12 types of principle organs. As the results, we could not find any mortality, clinical signs, changes in the body weight and gross findings except for significantly increase in body weight and gains at some periods and hypertrophy of popliteal lymph nodes in treated females. In addition, there were no abnormal changes related with MR extracts-treatment related abnormal changes in the organ weight and histopathology of principle organs except for increase of the frequency of hyperplasia of lymphoid cells and follicles in spleen and popliteal lymph nodes- considered as the results of pharmacological effects as enhance the immune system, and some sporadic accidental findings. The results obtained in this study suggest that the MR extracts does not cause any toxicological signs except for pharmacological effects of enhancement of immune system. The LD50 and approximate LD of MR extracts in both female and male mice were considered as over 2,000 mg/kg
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KEYWORD
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Mori Radicis cortex, water extracts, single oral dose toxicity, mice, histopathology
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