|
KMID : 1204320060220040361
|
|
Laboratory Animal Research
2006 Volume.22 No. 4 p.361 ~ p.365
|
|
|
Effect of the Extract of Herbal Drugs Mixture on Brain Function in Rats
|
|
Oh Yoon-Jo
Hue Jin-Joo
Lee Yea-Eun
Nam Sang-Yoon
Yun Young-Won
Jeong Jae-Hwang
Lee Sang-Hwa
Lee Beom-Jun
Ahn Byeong-Woo
Lee Ah-Ram
Li Lan
Lee Jung-Su
Cho Min-Hang
|
|
|
Abstract
|
|
|
|
Green tea, Crataegus oxycantha fruit, gingko leaves and tangleweed were known to increase blood circulation and improve brain function. The mixture containing green tea (50 g), Crataegus oxycantha fruit (50 g), gingko leaves (20 g), and tangleweed (20 g) was water-extracted and freeze-dried to powder. The pharmacological effect of the extract of herbal drugs on acetylcholinesterase (AChE) in an in vitro enzyme system and in rats was investigated. The extract of herbal drugs at the doses of 10, 25, 50 and 100 μg/ml decreased activity of AChE by 8.8, 22.1, 43.1 and 63.0%, respectively. The treatment of the extract of herbal drugs at the dose of 0.1 g/kg b.w. to rats for 5 and 10 consecutive days reduced AChE activity in the brain by 12.8 and 26.9 %, respectively, corresponding to increases by 26.4 and 59.7% in the concentration of acetylcholine (ACh) in the brain of rats, compared with the control rats. The levels of ATP in the brain also increased in treatment group in a time-dependent manner. The liver toxicity was not shown as determined by serum biochemistry. These results suggest that a composition of these herbal drugs may improve brain function by increasing the levels of acetylcholine and ATP.
|
|
|
KEYWORD
|
|
|
Green tea, Crataegus oxycantha fruit, gingko Leaves, tangleweed, acetylcholinesterase, brain function
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|