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KMID : 1204320060220040383
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Laboratory Animal Research
2006 Volume.22 No. 4 p.383 ~ p.387
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Immunomodulating and Antitumor Activities of the Protein Fraction of Korean Mistletoe in Mice
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Yoo Young-Choon
Lee Jung-Lim
Lee Kyung-Bok
Her Erk
Kim Jong-Bae
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Abstract
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Immunomodulating and antitumor activities of the protein fraction (KM-AS) isolated from Korean mistletoe (KM; Viscum album Coloratum) were investigated in mice. Treatment of KM-AS activated peritoneal macrophages to induce IL-1β in an in vitro experiment, and intravenous (i.v.) administration of KM-AS enhanced natural killer (NK) cell activity against Yac-1 NK-sensitive cells 2 days after administration. An i.v. administration of KM-AS (1 or 1.5 μg/mouse) 2 days before tumor inoculation significantly inhibited lung metastases of colon 26-M3.1 cells. The prophylactic effect of 1 μg/mouse of KM-AS on lung metastasis was almost the same with that of 100 μg/mouse of a water extract of KM (KM-110). Furthermore, multiple administrations of KM-AS given at 3 day-intervals after tumor inoculation led to a significant reduction of lung metastasis and suppression of the growth of B16-BL6 melanoma cells in a spontaneous metastasis model. These results suggest that KM-AS can activate NK cells and macrophages, and its immunomodulating activity contributes to the prophylactic as well as therapeutic inhibition of tumor metastasis.
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KEYWORD
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Korean mistletoe, protein fraction, macrophage, NK cell, antitumor activity
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