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KMID : 1204320060220040413
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Laboratory Animal Research
2006 Volume.22 No. 4 p.413 ~ p.415
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Extramedullary Plasmacytoma in a Dobermann Pinscher Dog
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Jo Hyun-Ye
Chang Dong-Woo
Na Ki-Jeong
Ahn Byeong-Woo
Yang Mhan-Pyo
Kim Il-Hwa
Kang Mi-Seung
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Abstract
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A 3-year-old male Doberman pinscher dog with anorexia and depression was referred to Veterinary Medical Center, Chungbuk National University. Serum biochemistry analysis data showed hypercalcemia, hypercholesterolemia and elevated levels of alanine aminotransferase and gamma-glutamyltransferase. Abdominal and thoracic radiographs and ultrasonographs revealed multiple masses in parenchymal organs including liver, spleen, kidney, sternal and pulmonary lymph nodes. The patient was euthanized with the owner`s agreement and autopsy was performed. Various-sized white, soft and ovoid masses were scattered throughout ileocecal area, kidneys, livers, and abdominal and thoracic walls. On cross sections of the involved organs, the masses were discrete and encapsulated with lobular appearances. Histopathologically the neoplasm was diagnosed as extramedullary plasmacytoma. The neoplastic cells were round to oval with basophilic plump cytoplasms and eccentrically located nuclei. The histological diagnosis was confirmed with positive immunohistochemistry against canine IgG in the cytoplasms.
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KEYWORD
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Doberman pinscher, tumor, plasma cell, extramedullary plasmacytoma
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