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KMID : 1204320060220040417
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Laboratory Animal Research
2006 Volume.22 No. 4 p.417 ~ p.419
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Application of Chronic Catheter Implantation with Tether System in the Rhesus Macaques (Macaca mulatta)
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Lee Jae-Il
Kang Byeong-Cheol
Lee Chi-Woo
Ahnn Kyoung-Ha
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Abstract
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A jacket and tethering system was used to maintain chronic catheters in monkeys, which provided catheter access and manipulability without further restraint. Surgical placement of catheters allowed for a common cutaneous exit and interface with the jacket and tether. A catheter made of silicone tubing 6 Fr was inserted via the femoral vein and passed to a point near the caudal vena cava. The two monkeys implanted catheters were monitored 2 to 3 times in every week whether catheter was available opening. Physical condition and hematologic profile were checked for inflammation or other complications as anorexia, depression, disorder of vital signs for several days. At an early stage, a leukocytosis demonstrated with neutrophilia against decreasing of lymphocytes. In vital signs, however, not appeared considerable changes in applied animals during the follow-up. And also, the newly manufactured cage was spacious enough to move free without any limitation. It suggests that chronic catheter implantation is useful in proceeding of clinical or pharmaceutical study for rhesus monkey and also easily applicable to a newly manufactured cage.
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KEYWORD
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Catheter, implantation, rhesus monkey, tethering system
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