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KMID : 1204320070230010077
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Laboratory Animal Research
2007 Volume.23 No. 1 p.77 ~ p.82
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Effects of Licorice (Glycyrrhiza glabra) on the Gene Expression of Glutathione Peroxidase in the Female Reproductive System of Rats
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Lee Se-Ra
Nam Sang-Yoon
Lee Beom-Jun
Kim Yun-Bae
Ahn Byeong-Woo
Baek In-Jeoung
Yon Jung-Min
Kim Mi-Ra
Jin Yan
Yun Young-Won
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Abstract
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To understand the antioxidative effect of licorice on the female reproductive system, we analyzed the mRNA expression patterns of glutathione peroxidase (GPx) family (type 1-4) in the ovary and uterus of rats exposed to licorice. Licorice, the root of the leguminous Glycyrrhiza, is one of the most frequently employed botanicals in foods and traditional medicines, which is known to have antioxidant, anti-tumor, anti-allergic and antiviral activities, in addition to estrogenic properties. However, there is no report on the effects of licorice in the reproductive organs. Licorice extracts (0, 0.5, 1, and 2 g/㎏ body weight) were treated to 8-week-old female rats for 4 weeks daily per oral. Total RNAs were extracted from ovary and uterus and then RT-PCR analysis was performed with the specific primers of each GPx enzyme. In ovaries, GPx1, GPx3, and GPx4 mRNA levels were slightly decreased compared with those of control group. Especially, GPx3 mRNA expression was decreased dose-dependantly in ovaries. However, GPx2 mRNA was weakly increased in ovary. On the contrary, the gene expression of GPx1-3 in uteri tended to increase slightly compared to control group. GPx4 mRNA expression was decreased by 0.5 g/㎏ of licorice in uterus, but increased by treatment with 1 and 2 g/㎏ of licorice. These findings indicate that licorice maybe differently influenced on the antioxidant systems of ovary and uterus.
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KEYWORD
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Licorice(Glycyrrhiza glabra), glutathione peroxidase(GPx), female reproductive organs
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