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KMID : 1204320070230010083
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Laboratory Animal Research
2007 Volume.23 No. 1 p.83 ~ p.87
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Skin Irritation and Sensitization Studies on a Disinfectant Composed of 4-Chloro-m-cresol and Didecyl Dimethyl Ammonium Chloride for the Bactericide and Viricide
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Chung Hee-Sik
Kim Suk
Lee Hu-Jang
Jung Won-Chul
Kim Dong-Hyeok
Kim Moo-Suk
Chun Myung-Sun
Lim Jeong-Ju
Shon Ho-Yeong
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Abstract
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This test was performed to evaluate the skin irritation and sensitization of Creocide, disinfectant, containing 10% 4-chloro-m-cresol and 10% didecyl dimethyl ammonium chloride as main ingredients. In primary skin irritation test, rabbits were dermally treated with Creocide for 24 hrs. The disinfectant did not induce any adverse reactions such as erythema and edema on intact skin sites, but on abraded skin sites, some rabbits showed very slight erythema and edema 24 hr after topical application. So, the disinfectant was classified as a practically non-irritating material based on the score 0.29 of primary irritation index. In the skin sensitization test, guinea pigs were sensitized with intradermal injection of 0.1 ㎖ Freund’s complete adjuvant emulsion (2-fold diluted), 0.1 ㎖ Creocide, and 0.1 ㎖ Creocide plus Freund’s complete adjuvant emulsion (1 : 1) for 24 hrs. After 1 week, Creocide was treated on the site of injection, and challenged 2 weeks later. Creocide did not induce any allergic reactions. Therefore, Creocide was graded as a weak material from 0 in both sensitization score and rate. From results of the present study, it is suggested that Creocide does not cause contact irritation and sensitization.
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KEYWORD
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Disinfectants, 4-chloro-m-cresol, didecyl dimethyl ammonium chloride, skin irritation, skin sensitization
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