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KMID : 1204320070230010089
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Laboratory Animal Research
2007 Volume.23 No. 1 p.89 ~ p.94
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Protective and Therapeutic Effect of HSMI on CCI₄ Induced Liver Dysfunction in Rats
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Kim Geun-Soo
Kang Jong-Koo
Lee Nam-Jin
You Jong-Hoon
Jeong Yu-Ri
Yang Bum-Hee
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Abstract
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Bromosulfalein (BSP) is a relatively nontoxic organic anion used as in vivo indicator of liver dysfunction. The purpose of this study was to investigate the effects of HSMI (6,8-epitrichioctanoic acid mixture) on carbon tetrachloride (CCI₄)-induced acute hepatotoxicity in Sprague-Dawley rats. The experimental groups have consisted of HSMI (50 or 200 ㎎/㎏ BW., p.o.), silymarin (80 ㎎/㎏ B.W., p.o.), vehicle control (CCI₄ alone) group and normal control group respectively. All rats except normal control group were treated with CCI₄. In the result of BSP clearance experiment by single i.p. dose of CCI₄ (20% in corn oil, 5 ㎖/㎏ B.W.), BSP was quickly removed in a time-dependent manner by HSMI oral administration. In the results of liver dysfunction experiment by four s.c. doses of CCI₄ (20% in corn oil, 2 ㎖/㎏ B.W., followed by 1 ㎖/㎏ B.W. on days 3, 7 and 10), oral administration HSMI (200 ㎎/㎏ B.W.) significantly decreased the serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) compared to CCI₄ alone treatment. In the histopathological findings, oral treatment with HSMI clearly reduced the vacuolar degeneration of hepatocytes compared to CCI₄ alone treatment. And the relative hapatoprotective efficacies of HSMI approximately were equal or above those of sylimarin. These results suggest that HSMI have the hepatoprotective activity and may be useful for therapy of hepatic damage.
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KEYWORD
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Carbon tetrachloride, HSMI(6, 8-epitrichioctanoic acid mixture), bromosulfalein clearance, hepatoprotection
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