|
KMID : 1204320070230010113
|
|
Laboratory Animal Research
2007 Volume.23 No. 1 p.113 ~ p.115
|
|
|
High Prevalence of Chronic Progressive Nephropathy in Old Sprague-Dawley Rats with ad Libitum Food Consumption
|
|
Park Young-Seok
Kim Ok-Jin
Lee Jin-Uk
|
|
|
Abstract
|
|
|
|
In this study, chronic progressive nephropathy (CPN) was detected with high prevalence in male Sprague-Dawley (SD) rats more than 1.5-year-old ages with ad libitum food consumption. The incidence of the disease in their group was 22.5%. Most of the affected rats developed proteinuria, hypoproteinemia and hypercholesterolemia, and some of them developed systemic edema and fatal death. A high concentration of blood urea nitrogen (BUN) and a low haematocrit value were also observed. The kidneys of severe cases showed a decrease in size and had a yellowish granular surface. The histopathological findings revealed tubule dilatation and tubular hyperplasia, interstitial inflammation and urinary casts. We suggested that these cases of nephrosis in old SD rats might be associated with a CPN, which is related with age and overfeeding, and slowly progressive nephropathy characterized by proteinuria and hypoalbuminemia.
|
|
|
KEYWORD
|
|
|
Nephrosis, nephropathy, old, Sprague-Dawley rat
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|