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KMID : 1204320070230020133
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Laboratory Animal Research
2007 Volume.23 No. 2 p.133 ~ p.138
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Effect of Hericium Gold® on an Alcoholic Fatty Liver
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Jeong Jae-Hyun
Kim Yun-Bae
Shin Sun-Hee
Park Dong-Sun
Jeon Jeong-Hee
Jung Dong-Hyun
Ryu Jae-Myun
Seo Im-Kwon
Lee Tae-Hee
Lee Seung-Ho
Hwang Seok-Yeon
Yeo Yeoung-Gil
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Abstract
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The improving efficacies of Hericium Gold® containing fermented extract of Hericium erinaceum on an alcoholic fatty liver investigated using alcohol plus a high-fat diet-induced steatosis model. Male Sprague-Dawley rats were orally administered with 6 ㎖/㎏ (15 ㎖/㎏ as 40% in water) of ethanol for 4 weeks, under simultaneous feeding of a high-fat diet containing 3% corn oil, 0.5% cholesterol and 0.1% cholic acid. Hericium Gold® (33, 100 or 300 ㎎/㎏) or its vehicle (water, 1 ㎖/㎏) was orally treated 30 min prior to ethanol administration everyday. The combinational treatment of ethanol and a high-fat diet slightly reduced feed consumption, leading to lowered body weight gain, and enhanced blood cholesterol and low-density lipoproteins (LDL) levels. Ethanol plus a high-fat diet induced hepatic congestion and steatosis, resulting in the increases in blood alanine transaminase (ALT) activity and hepatic lesions. Although a high dose (300 ㎎/㎏) of Hericium Gold® further suppressed feed consumption and body weight gain of Ethanol plus a high-fat diet-treated rats, it attenuated not only the increases in blood cholesterol, LDL, ALT and aspartate transaminase (AST) levels, but also hepatic congestion and hepatic lesions including lipid deposition. Taken together, the results suggest that Hericium Gold® possesses hepatoprotective activity against exposure to alcohol and dietary fats, and that could be a candidate for the improvement of alcoholic liver disorders.
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KEYWORD
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Fatty liver(steatosis), alcohol, high-fat diet, Hericium Gold®
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