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KMID : 1204320070230030265
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Laboratory Animal Research
2007 Volume.23 No. 3 p.265 ~ p.270
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A Minipig can Replace a Dog in Non-rodent Toxicity Study
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Lee Sang-Koo
Kweon Youn-Sang
Solis Chester D.
Rho Shin-Joung
Kim Tae-Ho
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Abstract
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This study was conducted to compare the difference of quantitative toxicity of a compound which has different metabolic pathways in minipig and beagle dog. Coumarin which has low toxic values in human and different metabolic pathways in these two animals was chosen as a test compound. In the single dose toxicity study conducted using minipig, maximum tolerable dose (MTD) of coumarin was determined to be 200 ㎎/㎏/day and liver was confirmed as a target organ. However, MTD value of coumarin in the dog study was 60-100 ㎎/㎏/day and target organs were liver and kidneys. Minipig which has similar metabolic pathway of coumarin with human showed similar acute toxicity when compared with previously published data. Although it is difficult to conclude without further toxicity studies, it was expected from this study that animals having similar metabolic pathways with human should be chosen during the toxicity studies of new chemicals to predict the accurate toxicity and target organs in the human.
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KEYWORD
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Minipig, dog, coumarin, single dose toxicity study
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