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KMID : 1204320070230030271
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Laboratory Animal Research
2007 Volume.23 No. 3 p.271 ~ p.275
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Evaluation on the Relative Biological Effectiveness of Neutrons with Regard to Prenatal Effects in Mouse
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Lee Hae-June
Kim Seong-Ho
Jang Jong-Sik
Ryu Si-Yun
Kim Joong-Sun
Jo Sung-Kee
Song Myoung-Sub
Back Nam-Woon
Moon Chang-Jong
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Abstract
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This study compared the effects of high linear energy transfer (LET) fast neutrons (35 MeV) on embryotoxicity of ICR mouse exposed to low LET 60Co gamma-rays. At 11.5 days after conception, pregnant mice were exposed to 0-4 Gy of gamma-rays or 0-1.6 Gy of neutrons. The animals were sacrificed on day 18 of gestation and the fetuses were examined for mortality, growth retardation, change in head size and any other morphological abnormalities. With increasing radiation dose, incidence of small head, growth retarded fetuses, cleft palate, dilatation of cerebral ventricle and abnormalities of the extremities in live fetuses rose. Neutron irradiation produced a greater proportion of offspring with very low body weight than with malformations when compared to gamma-rays. In the malformation frequency between 30% and 70%, the relative biological effectiveness (RBE) of the neutrons was 2.14 ± 0.48. These results indicate that the embryo exhibits a linear response to increasing doses of neutrons during the period of major organogenesis.
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KEYWORD
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Embryotoxicity, malformation, neutron, relative biological effectiveness(RBE)
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