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KMID : 1204320070230030285
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Laboratory Animal Research
2007 Volume.23 No. 3 p.285 ~ p.288
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Water Extract of Helicobacter pylori can Induce Caspase-3-Dependent Apoptosis in Cultured Gastric Parietal Cells
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Suzuki Hidekazu
Kim Ok-Jin
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Abstract
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Chronic Helicobacter pylori (H. pylon) infection has an estimated world wide incidence of 50% and it has been associated with the pathogenesis of gastroduodenal diseases namely chronic gastritis, peptic ulcer, MALT lymphoma and gastric cancer. Apoptosis is related with cell death and oncogenesis. Two kinds of gastric cell lines (mucous and parietal cells) were exposed with water extract of H. pylori (HPE) of previously defined VacA, urease, CagE and CagA status. The mouse gastric parietal cell line MGE507 and gastric epithelial cell line GSMO6 cells were cultured and used to study the difference of apoptotic expression against HPE. The expression of apotosis was evaluated in two cell lines. Both mucous and parietal cell lines induced caspase-3-dependent apoptosis by HPE. However, the expressed amounts were higher in parietal cells than mucous cells. It is concluded that apoptosis is expressed strongly by parietal cells following H. pylori infection. On our knowledge, this is the first report about the apoptosis expression of gastric parietal cells by H. pylori infection.
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KEYWORD
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Helicobacter, parietal cell, apoptosis, in vitro
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