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KMID : 1204320070230040385
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Laboratory Animal Research
2007 Volume.23 No. 4 p.385 ~ p.390
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Hepatoprotective Effects of the Water Extracts of Hovenia dulcis Thunb on Carbon Tetrachloride-Induced Hepatotoxicity in the Primary Cultures of Adult Rat Hepatocytes
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Kim Jong-Ho
Jeong Tae-Cheon
Hyun Sun-Hee
Lee Sang-Kyu
Kang Mi-Jeong
Yoon Soo-Hong
Kim Ju-Hyun
Seo Young-Min
Jeon Tae-Won
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Abstract
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Protective effects of four different water extracts of Hovenia dulcis Thunb against carbon tetrachloride (CCl₄)-induced toxicity were investigated in the primary cultures of adult rat hepatocytes. The individual extracts used in these studies were prepared from fruits, seeds, leaves and tubes. Treatment of hepatocyte cultures with the extracts provided a significant protection from the increased lactate dehydrogenase activity induced by CCl₄. Particularly, the fruit extract was the most effective against CCl₄-induced hepatotoxicity in the primary cultures of rat hepatocytes. The results demonstrated that the extract may have the protective effect against CCl₄-induced toxicity in hepatocyte cultures.
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KEYWORD
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Hepatoprotection, Hovenia dulcis Thunb, carbon tetrachloride (CCl4), primary cultures, rat hepatocytes, lactate dehydrogenase (LDH) leakage
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