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KMID : 1204320070230040397
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Laboratory Animal Research
2007 Volume.23 No. 4 p.397 ~ p.400
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Muscle Tissue Distribution Level after Dipping Administration of Neomycin in Olive Flounder (Paralichthys olivaceus), Rockfish (Sebastes schlegeli), and Red Sea Bream (Pagrus major)
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Chung Hee-Sik
Kim Suk
Lee Hu-Jang
Jung Won-Chul
Kim Dong-Hyeok
Kim Gon-Sup
Shon Ho-Yeong
Lim Jeong-Ju
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Abstract
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After one day treatment with dipping water at a dose of neomycin 140 ㎎/ton water, the residue depletion of neomycin was investigated in cultured marine fishes olive flounder (Paralichthys olivaceus), rockfish (Sebastes schlegeli), and red sea bream (Pagrus major). Muscles of fishes were sampled on 1st, 2nd, 3rd, 4th, and 5th day after treatment. Concentrations of neomycin in muscles were determined by high performance liquid chromatography after SPE column extraction. The recovery rates of neomycin in muscle samples ranged from 78.4 to 84.3% for the concentration of neomycin 0.1 ㎎/㎏, and from 82.5 to 94.7% for the concentration of 0.2 ㎍/g. On the 1st day after treatment, neomycin concentrations were 0.125, 0.117, and 0.142 ㎍/g in muscles of olive flounder, rockfish, and red sea bream, respectively. Residue concentrations of all samples were decreased to lower than 0.1 ㎍/g, the detection limit, on day 2. According to the results of the present study, a withdrawal period of neomycin is proposed on 3 days after one day treatment with dipping administration at a dose of 140 ㎎/ton water to avoid the presence of excessive residues of the edible muscles of olive flounder, rockfish, and red sea bream.
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KEYWORD
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Neomycin, HPLC, olive flounder, rockfish, red sea bream
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