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KMID : 1204320070230040411
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Laboratory Animal Research
2007 Volume.23 No. 4 p.411 ~ p.418
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Adequate Concentration of Local Anesthetic for Cranial Cervical Ganglion Block in Beagle Dogs: Lidocaine
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Park Woo-Dae
Kim Hwi-Yool
Choi Seok-Hwa
Bae Chun-Sik
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Abstract
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There are many of concentrations of local anesthetic recommended for sympathetic nerve blocks with the exception of those for a cranial cervical ganglion block in dogs. The aim of this study was to determine the optimal lidocaine concentration for a cranial cervical ganglion block in dogs. Forty-five beagle dogs were divided randomly into four experimental groups (2, 1, 0.5 and 0.25% lidocaine group). The block was performed by one person. The success block rate, onset time, action duration time, complication rate and the degree of the parameters (eye surface temperature, miosis, ptosis, nictitating membrane prolapse and conjunctiva and sclera congestion) were measured according the time course. A successful block was observed in all dogs in the 2% and 1% lidocaine groups but in only 60% in the 0.5% lidocaine group and 20% in the 0.25% lidocaine group. The onset time of the 0.25% lidocaine group was significantly longer than those of the other groups (P ＜ 0.05). The action duration time of the 0.5% and 0.25% lidocaine groups was significantly shorter than that of the 2% and 1% lidocaine groups (P ＜ 0.05). The incidence of complications was higher in the 2% and 1% lidocaine groups than in the 0.5% and 0.25% lidocaine groups (P ＜ 0.05). The intensity of the parameters reached their maximum within 5 to 10 min. There were significant differences in the incidence of complications. There was a much higher incidence of eye surface temperature elevation in the 2% and 1% lidocaine groups than in the 0.25 and 0.5 % lidocaine groups (P ＜ 0.05). These results suggest that 1% lidocaine is most suitable for a successful and safe cranial cervical ganglion block in dogs, and these parameters are expected to be useful for clinical studies on sympathetic disorders.
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KEYWORD
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Concentration, miosis, nerve block, nictitating membrane prolapse, ptosis
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