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KMID : 1204320070230040427
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Laboratory Animal Research
2007 Volume.23 No. 4 p.427 ~ p.434
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Effect of Feed Restriction in Modeling of Dietary Obesity
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Cho Yeoung-Mi
Kim Chang-Hwan
Kim Yun-Bae
Shin Sun-Hee
Park Dong-Sun
Ji Hyeong-Jin
Jeon Jeong-Hee
Jang Min-Jung
Kim Jwa-Jin
Kim Jae-Wook
Baek Seong-Jin
Hwang Seock-Yeon
Kim Gon-Hyung
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Abstract
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Ad libitum feeding of normal diet to rats usually leads to overweight, showing higher body-mass index than 25, while the supplementation of high (20-40%) content of lard or beef tallow in the diet to make a high-fat diet (HFD)-induced obesity rather decreases body weights partially due to decrease in feed intake of HFD or occurrence of diarrhea. In our study, for modeling dietary obesity, rats were subjected to feed restriction by 20 and 40% with normal diet or HFD supplemented with 25% of lard for 6 weeks. Ad libitum (100%) feeding of HFD decreased body weight gain and body fat in rats, resulting from a lower feed intake and transient diarrhea, compared to that of animals fed normal diet. In comparison with ad libitum-feeding groups, HFD restricted to 60 and 80% resulted in higher body weight gain and body fat compared with the normal diet with corresponding restriction to 60% or 80%. The changes in body and fat weights exhibited a good relationship with blood lipids profiles and leptin level in feed restricted groups. In addition, body fat and lipid profiles were confirmed to be parallel with the lipid accumulation in the liver and blood parameters associated with liver function. Based on the results, it is suggested that an appropriate degree (80%) of dietary restriction could be a candidate of modeling HFD-induced obesity for the screening of antiobesity substances.
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KEYWORD
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Dietary obesity, high-fat diet (HFD), feed restriction, body weight, body fat, triglycerides, leptin
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