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KMID : 1204320080240010039
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Laboratory Animal Research
2008 Volume.24 No. 1 p.39 ~ p.44
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Effect of β-Glucan from Aureobasidium pullulans on Rat Rib Fracture Healing
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Lee Hyeung-Sik
Yang Kun-Ju
Shin Hyun-Dong
Park Bok-Ryeon
Cho Hyung-Rae
Jang Hee-Jeong
Moon Seung-Bae
Kim Lin-Su
Ku Sae-Kwang
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Abstract
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The effects of β-glucan from Aureobasidium pullulans SM-2001 were observed on the rat rib fracture healing. 31.25, 62.5 and 125 ㎎/㎏ of β-glucan were orally administered once a day for 13 days to ribfractured rats from 6 h after operation, and changes on the volume, mineral density, strength and histopathology of callus were observed. The effects of β-glucan were compared with 10 ㎍/㎏ of human parathyroid hormone 1-34 (hPTH) subcutaneously treated group. Treatment of β-glucan induced dosedependent increases on the callus mineral density and strength with dramatical decreases on the callus volume. In addition, more active cartilaginous ossifications were observed in β-glucan treated groups as compared with rib-fractured control; hence, the callus connective tissues and cartilaginous tissues were decreased, and consequently, osteoid tissues in callus were dramatically increased at histopathological observation. It is, therefore, concluded that β-glucan used in the present study accelerated the fracture healing, especially on the ossification. 125 ㎎/㎏ of β-glucan shows similar or slight lower effects on accelerating facture healing as compared with hPTH 10 ㎍/㎏.
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KEYWORD
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β-Glucan, Aureobasidium pullulans, rib fracture healing, histopathology, rat
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