|
KMID : 1204320080240010137
|
|
Laboratory Animal Research
2008 Volume.24 No. 1 p.137 ~ p.141
|
|
|
Eye Irritation, Skin Irritation and Skin Sensitization Studies on Surfactin C
|
|
Lim Jong-Hwan
Rhee Man-Hee
Yun Hyo-In
Hwang Mi-Hyun
Kim Myoung-Seok
Hwang Youn-Hwan
Park Byung-Kwon
Park Seong-Chun
|
|
|
Abstract
|
|
|
|
This study was carried out to investigate the skin and eye irritation of surfactin C in rabbits and skin sensitization of surfactin C in guinea pigs. Skin and eye irritation test were performed in New Zealand white rabbits according to Korea Food and Drug Agency (KFDA) guidelines for toxicological test. Buehler method was applied to evaluate the sensitization potential of surfactin C in Hartley guinea pigs. Surfactin C caused slight conjunctival discharge and redness in rabbits by its mechanical irritation. However, it did not show any skin irritation in rabbits and skin sensitization in guinea pigs. The results indicated that surfactin C was a minimal irritant and non-irritant material on eye and skin, respectively. Moreover, it did not cause any skin sensitization in guinea pigs.
|
|
|
KEYWORD
|
|
|
Skin irritation, eye irritation, skin sensitization, surfactin C
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|