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KMID : 1204320080240010143
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Laboratory Animal Research
2008 Volume.24 No. 1 p.143 ~ p.150
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Genotoxicity Test on 3,9-Diferuloyl-6-oxopterocarpen, a New Agent Candidate for Anti-aging Material
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Jung Yu-Ri
Pyo Hyeong-Bae
Kang Jong-Koo
Lee Nam-Jin
Park Seong-Min
You Jong-Hoon
Kim Geun-Soo
Lin Chun-Mei
Shu Zheng-Mei
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Abstract
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To perform the safety studies on 3,9-diferuloyl-6-oxopterocarpen (DFO), we accomplished the reverse mutation assay in Salmonella typhimurium and Escherichia coli, in vitro chromosomal aberration assay on Chinese hamster lung cell and in vivo bone marrow micronucleus test in male ICR mice. In the reverse mutation assay, this material treatment at the dose range up to 5,000 ㎍/plate did not induce mutagenicity in Salmonella typhimurium TA98, TA100, TA1535, TA1537 and in Escherichia coli WP2uvrA-with and without metabolic activation. In the in vitro chromosomal aberration assay, this material did not increase the number of cells having structural or numerical chromosome aberration. In the in vivo bone marrow micronucleus assay, no significant increase in the occurrence of micronucleated polychromatic erythrocytes was observed in male ICR mice administered this material. In conclusion, we suggested that DFO have no genotoxicity in reverse mutation assay, in vitro chromosomal aberration assay and in vivo bone marrow micronucleus test.
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KEYWORD
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3,9-Diferuloyl-6-oxopterocarpen, reverse mutation assay, chromosomal aberration assay, micronucleus test
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