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KMID : 1204320080240010151
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Laboratory Animal Research
2008 Volume.24 No. 1 p.151 ~ p.156
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New Establishment of the Facility for Gnotobiotic Miniature Pigs
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Lee Young-Ah
Han Jin-Soo
Cho Yoon-Ju
Lee Hoon-Taek
Kim Yoon-Berm
Baik Eun-Ki
Ju Young-Duk
Lee Jin-Uk
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Abstract
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The research on the organ transplant between xenogeneic animals become a new window of the life science as high interesting for the human life extension and high technology of medical science. Miniature pig is one of the most representative animal among the candidate animals. It mostly resembles humans in physiological and anatomical manner and shows high availability for the gnotobiotic breeding and clone production. Thus, it is quite important to establish the infra structure for the production of bio organs of gnotobiotic mini pig. The laboratory animal research center in Konkuk University has opened the gnotobiotic miniature pig barrier facility equipped with the most high-end equipment, such as digital automatic environmental control system. Temperature and humidity of this new facilities is regulated to sustain 23±2℃ and 50±5%. The air is to be ventilated 25 times maximum per hour. And the room pressure can be maintained 22 mmAq. In addition, the ion cluster and carbon filters are installed to deodorize heavy odor in the animal room. The facility of gnotobiotic production was constructed with the cutting-edge technologies of intelligent building including automation control system. The precise air pressure control system enables the facility to be fully operative within high pressure atmosphere. The closed circuit surveillance camera system in the laboratory and breeding room provides security of the facility and the condition of animals. This facility will be served as an important infra structure for the research and development of bio organ transplant.
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KEYWORD
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Gnotobiotic, miniature pig, breeding facility, automatic control
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