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KMID : 1204320080240020193
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Laboratory Animal Research
2008 Volume.24 No. 2 p.193 ~ p.199
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Validation Study of Auditory Middle Latency Response in Mouse Model
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Hong Bin-Na
Kang Tong-Ho
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Abstract
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Auditory middle latency response (AMLR) is an important biosignal of auditory pathway. Validated-AMLR test is required in research for neurodiagnosis and preclinical study for auditory diseases. However, the amplitude of AMLR is small and the latency time of AMLR has poor reproducibility. In this study, we have performed the validation of AMLR test in ketamine-anesthetized mouse model. The latency and amplitude of AMLR increased with higher ketamine dosage. The profiles of latency time were similar but the profiles of amplitude showed a decrease. When body temperature was lower or higher than normal temperature, the latency of AMLR increased. A bandpass filter of 10-250 ㎐ was used. It had the lowest relative standard deviation and its morphology was reliable to analyse AMLR responses. With increase in the stimulus rate, there was decrease in the amplitude of AMLR. Our investigation might reduce relative standard variations of AMLR and enhance the reproducibility of AMLR tests on ketamine-anesthetized mouse models.
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KEYWORD
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Validation, auditory middle latency response (AMLR), ketamine, mouse
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