|
KMID : 1204320080240020235
|
|
Laboratory Animal Research
2008 Volume.24 No. 2 p.235 ~ p.240
|
|
|
Skin Irritation and Sensitization Studies on Rosin® Powder
|
|
Ryu Jae-Myun
Kim Si-Kwan
Kim Yun-Bae
Hwang Seock-Yeon
Seo Im-Kwon
Kim Tae-Myoung
Hong Seung-Bok
|
|
|
Abstract
|
|
|
|
Primary skin irritation and skin sensitization induced by Rosin®, an extract of pine tree, were assessed in rabbits and guinea pigs, respectively, according to the guidelines of Korea Food and Drug Administration. In primary skin irritation test, 5% and 10% of Rosin® (in 80% ethanol) exhibited mean score 1.17 and 1.33, respectively, leading to primary irritation indices (PII) of 0.29 and 0.33. Thus, the test compound Rosin® was evaluated to be a ‘non-irritant’ material. In skin sensitization study using guinea pig maximization test (GPMT), 5% and 10% Rosin® did not induce erythema or edema, displaying sensitization score 0 and rate 0%, whereas 0.1% 2,4-dinitrochrolobenzene (DNCB), a positive control, induced sensitization scores 1-2 and rate 80%. Therefore, Rosin® and DNCB were classified to grade Ⅰ and Ⅳ, indicating weak and strong sensitizers, respectively. Taken together, it is suggested that Rosin® is a pratically-safe material to skin without potential of irritation or allergic sensitization.
|
|
|
KEYWORD
|
|
|
Rosin®, skin irritation, sensitization, guinea pig maximization test (GPMT)
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|