|
KMID : 1204320080240020241
|
|
Laboratory Animal Research
2008 Volume.24 No. 2 p.241 ~ p.247
|
|
|
Antidiabetic Effect of Cultured Ginseng Root Extracts in Type 2 Diabetic Mice
|
|
Lee Nam-Jin
Kang Jong-Koo
Paek Kee-Yoeup
Jung Yu-Ri
Lin Chun-Mei
|
|
|
Abstract
|
|
|
|
Korean ginseng (Panax ginseng C.A. Meyer) has been documented as a traditional treatment for diabetes, hyperglycemia and hyperlipidemia. The aim of this study was to investigate the antidiabetic effect of the cultured ginseng roots extracts (CGRs) in C57BL/KsJ db/db mice, a non-insulin-dependent diabetes mellitus animal model. CGRs were orally administered for a 10-week period and indices of diabetes including serum glucose, insulin, glycosylated hemoglobin (HbA1C), total cholesterol and triglycerides (TG) were measured. CGRs exhibited improving effects on diabetes indices in comparison with those of vehicle-treated mice; the plasma level of insulin was significantly increased, followed by improvement of glucose tolerance. The blood level of the HbA1C was also attenuated by CGRs treatment. In addition, the levels of total cholesterol and TG in CGRs-administered db/db mice were greatly reduced to the level of normal mice. Separately, the antidiabetic activities of the CGRs were correlated with the marked increase in the insulin-containing cells in islets from immunohistochemical analysis of pancreas. The results support that CGRs are beneficial for the improvement of type Ⅱ diabetes.
|
|
|
KEYWORD
|
|
|
Non-insulin-dependent diabetes mellitus, antihyperglycemia, antihyperlipidemia, cultured ginseng roots extracts (CGRs)
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|