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KMID : 1204320080240020257
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Laboratory Animal Research
2008 Volume.24 No. 2 p.257 ~ p.262
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Effects of Ginseng Extracts on the Gene Expression of Glutathione Peroxidase in the Female Reproductive System of Mice
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Kim Mi-Ra
Kim Yun-Bae
Baek In-Jeoung
Yon Jung-Min
Lee Se-Ra
Yun Young-Won
Nam Sang-Yoon
Lee Beom-Jun
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Abstract
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Ginseng has been extensively used around the world for several thousand years as a food or a drug. Constituents in ginseng are known to have several activities such as antioxidant, anti-tumor, anti-stress, and anti-fatigue activities. In this study, we investigated the effects of Korean ginseng on the antioxidant system of female reproductive organs in mice. We analyzed the mRNA expression patterns of glutathione peroxidase (GPx) family in the reproductive organs of mice exposed to Korean ginseng. Korean ginseng extracts (0, 20, 200, and 2,000 ㎎/㎏ body weight) were treated daily by gavage to 8-week-old female mice for 5 weeks. Total RNAs were extracted from ovary and uterus, and then RT-PCR analysis was performed with the specific primers of each GPx genes. The cytosolic GPx mRNA expression was similar to control group in ovaries, but it was slightly increased in the uterus at all the doses of Korean ginseng. Gastrointestinal GPx mRNA was not changed in ovary, but was slightly affected in uterus. On the contrary, The phospholipid hydroperoxide GPx mRNA was weakly increased in ovary and uterus, but it was not significant difference. These findings suggest that Korean ginseng induces the slight increase on the expression of GPx genes in uterus rather than ovary, although the values didn’t show a significant difference.
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KEYWORD
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Korean ginseng, glutathione peroxidase (GPx), ovary, uterus
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