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KMID : 1204320080240020267
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Laboratory Animal Research
2008 Volume.24 No. 2 p.267 ~ p.269
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Histopathological Comparison of Atopic-Like Dermatitis by Two Allergens in Nc/Nga Mice
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Shim Se-Hwan
Shin Sung-Shik
Kwon Jung-Kee
Lim Sun
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Abstract
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Atopic dermatitis (AD) consists of two main stages, the acute stage and the chronic stage. TH2 lymphocytes have a major contribution to AD immune response in acute stage, TH1 immune response in chronic stage. We here demonstrated the atopic-like dermatitis by repeated two allergens treatment, dermatophagoides pteronyssinus crude extract (DPE) and picryl chloride (PC), with histopathological investigation. Histopathologically, PC-treated Nc/Nga mice were demonstrated much more infiltration of macrophages and fibroblast, which are effecter cells in TH1 immune response. According to the differences of TH1/TH2 immune response, we suggest that AD model by DPE-treated, which are showed TH2 immune response, is more suitable for the observations of progressive histopathological change in AD skin lesions.
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KEYWORD
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Atopic dermatitis (AD), Nc/Nga mouse, picryl chloride (PC), dermatophagoides pteronyssinus crude extract (DPE)
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