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KMID : 1204320080240030413
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Laboratory Animal Research
2008 Volume.24 No. 3 p.413 ~ p.420
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Dose-Dependent Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Male Guinea Pigs
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Hwang Seok-Yeon
Kim Si-Kwan
Wee Jae-Joon
Kim Yun-Bae
Kyung Jong-Soo
Hong Seung-Bok
Yang Jin-Bae
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Abstract
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This study was carried out to determine the dose-dependent toxic response of male guinea pigs to 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD). Male Hartley guinea pigs (200±20 g) received single intraperitoneal administration of 2,3,7,8-TCDD at doses of 0.1, 0.25, 0.5 or 1 ㎍/㎏. Body weight gain, organ weights, blood biochemistry and sperm quality (sperm head counts and motility pattern) were determined. Body weight, testicular weight, sperm head counts and ratio of sperm with straightforward progressing were significantly decreased by 2,3,7,8-TCDD in a dose-dependent manner. Blood biochemistry panels were worsened remarkably by 2,3,7,8-TCDD exposure. These results provide with information on the dose-responses of male guinea pigs to 2,3,7,8-TCDD, especially on the toxicity of testes, the most-sensitive target organ.
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KEYWORD
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2,3,7,8-Tetrachlorodibenzo-p-dioxin(2,3,7,8-TCDD), dose-dependent toxic response, testicular toxicity, blood biochemistry, guinea pigs
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