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KMID : 1204320080240030429
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Laboratory Animal Research
2008 Volume.24 No. 3 p.429 ~ p.431
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Malignant Aortic Body Tumor in Female Sprague-Dawley Rat
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Cho Wan-Seob
Kim Seung-Yeul
Choi Mi-Na
Jeong Ja-Young
Han Beom-Seok
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Abstract
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A malignant aortic body tumor was diagnosed in a 2-year-old female Sprague-Dawley (SD) rat. An oval shaped, rubbery mass approximately 2×3 mm in size was found at the heart base. Microscopically, the tumor was partially encapsulated and it protruded into the endocardium and it had focally infiltrated the myocardium of the left atrium. The tumor cells were partially lobulated with a thin fibrovascular stroma with numerous small nerves. The tumor emboli were seen in the blood vessels of the heart base. The nuclei varied in size and shape, but they were usually eccentric, round to oval and mildly pleomorphic with finely clumped chromatin and one or two prominent nucleoli were present. Rare mitoses, rare multinucleated giant cells, macrophages and peripheral lymphoid aggregates were visible. The individual cells showed degeneration, and necrosis was noted within the tumor mass. Immunohistochemically, the tumor cells expressed neuron-specific enolase (NSE) and chromogranin A, and these reactions were consistent with a neuroendocrine tumor. S-100 protein-positive cells that were reminiscent of sustentacular cells occurred singly or in small clusters within the tumor cell clusters.
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KEYWORD
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Aortic body tumor, immunohistochemistry, Sprague-Dawley rat
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