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KMID : 1204320080240030447
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Laboratory Animal Research
2008 Volume.24 No. 3 p.447 ~ p.452
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Defects in the Vestibular Systems in the Circling Mouse
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Shin Mi-Jung
Lee Jeong-Han
Yu Dong-Hoon
Kim Bong-Soo
Kim Hei-Jung
Lee Nam-Seob
Jeong Young-Gil
Park Chan-Ny
Hyun Byung-Hwa
Lee Sang-Gyu
So Hong-Seob
Park Rae-Gil
Ryoo Zae-Young
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Abstract
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We have identified deafness of circling mice because of its inner ear abnormalities; degenerated cochlea and reduced cellularity in the spiral limbus. Circling mice become hyperactive at approximately 7 days of age and then begin to exhibit circling behavior. The circling behavior of circling mice might be highly correlated with the vestibular system. The inspection of the epithelia and ganglion neurons in vestibule revealed mild abnormalities: some hair cells in the ampulla tended to have longer stereocilia and the numbers of ganglion cells were remarkably reduced compared to heterozygous mice. The reduced cell density in the vestibular neurons is thought to be the main reason for the phenotypic abnormalities. The circling mutant cerebellum is grossly normal, with characteristic lobulation and lamination in cresylvioletstained sections. The thickness of the granular layer, distributions of stellate cells and basket cells, and morphology of Purkinje cells of the circling homozygous mutant were normal. This suggests that the abnormal behavior of the circling (cir/cir) mouse is not the results of the morphological defects in the cerebellum.
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KEYWORD
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Circling mouse, vestibular systems, hair cell, vestibular neurons
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