KMID : 1204320080240030453
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Laboratory Animal Research 2008 Volume.24 No. 3 p.453 ~ p.455
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Analysis of Body Composition Using the LaTheta, Experimental Animal Computer Tomography System
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Shim Se-Hwan
Kwon Jung-Kee
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Abstract
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The aim of this paper is to report experimental animal computer tomography (CT) scanner, LaTheta, for in vivo experiments. The LaTheta CT scanner enables us to analyze several parameters such as body fat and bone measurement without any dissection and with minimum of radiation dose. In the present study we showed that LaTheta-based analysis allows the evaluation of fat volume and bone mineral density (BMD) in gad (UCH-L1 knockout) mice compare with wild-type mice. Male gad mice evidenced a significantly decreased cortical and spongy bone BMD rate in the femora. In summary, the LaTheta CT scanner is a new instrument that offers applicable methodology for quantitative analysis of body fat and various bone properties.
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KEYWORD
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Bone, fat, LaTheta, gad mice
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