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KMID : 1204320080240040593
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Laboratory Animal Research
2008 Volume.24 No. 4 p.593 ~ p.599
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Effects of Needle Electrode electrical stimulation on rat brain by Ischemia-induced Common Carotid Artery Occlusion
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Kim Sung-Won
Kim Byung-Ki
Lee Jung-Sook
Kim Ji-Sung
Song Chi-Won
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Abstract
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The aim of this study to investigate the effects of needle electrode electrical stimulation (NEES) on ischemia-induced Common Carotid Artery Occlusion. This Ischemia model was used rat brain that completely occluded with non-absorbent suture thread and kept for 5 minutes. Then suture were removed to allow the reperfusion of blood. The test groups were divided into three; the control group without common carotid artery ligation, the GI group in which global ischemia was induced through occlusion of common carotid artery and the NEES group in which NEES used after the global ischemia. NEES was conducted at the meridian points called Choksamni (ST 36) at 12, 24, 48 hours after blood reperfusion. The immune-reactive cells both Bax and caspase-3 indicates the apoptosis were high in the group GI comparing to NEES group. Cox-2 and IL-6 indicates the inflammation were high in the GI comparing to NEES groups. These results suggest that the NEES treatment has the beneficiary effects on ischemia.
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KEYWORD
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NEES, ischemia, apoptosis, inflammation, necrosis, reperfusion
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