|
KMID : 1204320080240040623
|
|
Laboratory Animal Research
2008 Volume.24 No. 4 p.623 ~ p.629
|
|
|
Gene Expression Analysis in a Transgenic Mice Expressing NSE-controlled Tau for Alzheimer’s Disease Model
|
|
Woo Jong-Min
Park So-Jung
Kim Chuel-Kyu
Kang Ho-Il
Shim Sun-Bo
Lee Su-Hae
Sin Ji-Soon
Bae Chang-Joon
Kim Sang-Seop
Jang Mee-Kyung
Kim Byoung-Guk
|
|
|
Abstract
|
|
|
|
Alzheimer’s disease is a progressive brain disorder cytopathologically characterized by beta amyloid plaques consisting of β-amyloid peptides and neurofibrillary tangles consisting of hyperphosphorylated tau proteins. Transgenic mice expressing NSE/htau23 human wild tau exhibit behavior deficits and the modulated phosphorylations of tau, GSK3β, and β-catenin. The aim of the present study was to identify differentially expressed genes during tau pathology in the transgenic mice. These mice display Alzheimer’s disease features of neurodegeneration and tau hyperphosphorylation. Using Illumina gene expression beadchips, we compared hippocampal mRNA levels between 6 month-old transgenic mice and 12 month-old transgenic mice. We identified total 28 genes that were expressed greater than 2-fold higher or lower with a p value ＜0.05. Of these, 17 genes were up-regulated and 11 genes were downregulated. Theses gene profiles, therefore, provide novel targets for future molecular and genetic information on Alzheimer’s disease.
|
|
|
KEYWORD
|
|
|
Microarray, transgenic mice, tau
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|