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KMID : 1204320090250010007
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Laboratory Animal Research
2009 Volume.25 No. 1 p.7 ~ p.13
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Subacute Toxicity Study of CS682, a Fermentation Product of Korean Soil Bacteria, in Rats
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Shin In-Sik
Lee Jong-Chan
Park Na-Hyeong
Kang Sung-Soo
Moon Chang-Jong
Kim Seong-Ho
Shin Dong-Ho
Yoo Jin-Cheol
Kim Jong-Choon
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Abstract
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The present study was carried out to investigate the potential subacute toxicity of CS682, a fermentation product of Korean soil bacteria, by 3-week repeated oral administration in Sprague-Dawley rats. The test substance was administered once daily by gavage to male and female rats at dose levels of 0,100, 300, and 1,000 ㎎/㎏/day for 3 weeks. During the test period, clinical signs, mortality, body weights, food consumption, ophthalmoscopy, urinalysis, hematology, serum biochemistry, gross findings, organ weights, and histopathology were examined. Throughout the study period, no treatment-related deaths were observed. There were no treatment-related effects on clinical signs, food consumption, ophthalmoscopy, urinalysis, hematology, serum biochemistry, necropsy findings, organ weights, and histopathology in any treatment group. Based on these results, it was concluded that the 3-week repeated oral administration of CS682 to rats did not cause any adverse effects in rats at dose levels of ≤1,000 mg/kg/day. Under these experimental conditions, the NOAEL of CS682 was considered to be over 1,000 mg/kg/day for both sexes.
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KEYWORD
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Feed additive, CS682, repeated dose toxicity, NOAEL, rat
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