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KMID : 1204320090250010015
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Laboratory Animal Research
2009 Volume.25 No. 1 p.15 ~ p.18
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Colocalization of Calcitonin Gene-Related Peptide and Substance P in the Purkinje Cells in the Colchicine-Treated Gerbil
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Choi Jung-Hoon
Lee Chung-Hyun
Yoo Ki-Yeon
Won Moo-Ho
Hwang In-Koo
Lee Yun-Lyul
Shin Hyung-Cheul
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Abstract
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The aim of the present study was to determine the distribution of calcitonin gene-related peptide (CGRP) and substance P (SP) in the gerbil cerebellum by immunohistochemical method. After injection of colchicine into the lateral ventricle, CGRP and SP immunoreactions were detected in Purkinje cells and their dendrites. We also examined the colocalization of these neurotransmitters in Purkinje cells in consecutive sections. About 20% of CGRP immunoreactive Purkinje cells colocalized with SP contained Purkinje cells in the gerbil cerebellum. These results suggest that CGRP and SP may have a potential for playing a complex role in modulating circuitry in the cerebellar cortex of the gerbil.
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KEYWORD
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CGRP, SP, colocalization, Purkinje cell, gerbil cerebellum
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